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REVEAL Neuronal microscopy for cell behavioural examination and manipulation

To achieve this goal, we will develop the necessary tools and the first instruments that will demonstrate the feasibility and the power of this new microscopy framework. In particular, we will develop a ‘cell picking neuronal microscope’ that will allow us to detect and collect different subtype of liver cells that are due to become tumoral and analyse them ahead of tumour manifestation. This analysis will help us to characterize the cellular heterogeneity known to exist at the origin of liver cancer. It will provide a direct mapping between cellular phenotypes observed under microscope and gene expression present in the early stages of liver cancer. Overall, we are thus defining a novel methodology, giving a central place to neuronal microscopy in the understanding of the cellular origin of the diseases.

REVEAL is a multidisciplinary project engaging 7 EU partners (2 being SMEs) from 4 countries covering the RTO, academic and industrial worlds, including medical doctors. An implementation plan is presented in the form of 6 work packages, 4 of them being technical. Synergy in communication and dissemination by the several partners and stakeholders will permit to maximize the project impact. Solutions to overcome the technological barriers, as well as appropriate deliverables, tasks, milestones and risks are presented, in order to complete the project objectives in due time. The REVEAL project outcomes are fully in line with the H2020 ICT-36-2020 call, subtopic iv, as it will develop novel methods and devices as research tools to understand the cellular origin of diseases.

 

Under Project REVEAL we will develop the necessary tools and the first instruments that will demonstrate the feasibility and the power of this novel microscopy framework. 

As a first test, we will target the cellular heterogeneity that lies at the origin of liver cancer. 

Once developed, the ‘cell-picking neuronal microscope’ will allow us to detect, identify and select pre-cancerous liver cells from a heterogenous mix and analyse them ahead of tumour manifestation. 

It will directly map cellular phenotypes observed under the microscope to gene and protein expression programs and cellular ultra-structures present in early stages of the disease. 

Overall, we are buliding an innovative and disruptive photonic tool,  which gives a central place to neuronal microscopy in the understanding of the cellular origin of the diseases.

partners / contact

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

[ CEA ]

France

Cedric ALLIER

Cedric ALLIER

IPRASENSE

[ IPRASENSE ]

France

Geoffrey ESTEBAN

Geoffrey ESTEBAN

ECOLE NORMALE SUPERIEURE DE LYON

[ ENS LYON ]

France

Kiran PADMANABHAN

Kiran PADMANABHAN

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

[ LMU ]

Germany

Maria ROBLES

Maria ROBLES

FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO

[ PCLM ]

Italy

Luca VALENTI

Luca VALENTI

ALS AUTOMATED LAB SOLUTIONS GMBH

[ ALS ]

Germany

Susanne FREYBERG

Susanne FREYBERG

POLITECHNIKA WARSZAWSKA

[ WUT ]

Poland

Wojciech KRAUZE

Wojciech KRAUZE

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101016726 . This publication [communication] reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

graph - chart

Start 01/01/2021
25% 27/11/2021
End 31/12/2024
Budget allocation . M€ Budget allocation
Effort 634 p*m Effort
Effort 13 persons Full time equivalent

news

Reveal trainings for project partners

2021-11-09

When you deal with matter as complex as we do in Reveal Project, training and constant learning is a must. That's why we are organisi...

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Meet our new colleague - Sanket Nagarkar

2021-10-21

We would like to welcome onboard of Reveal project our new recruit and postdoctoral researcher Sanket Nagarkar, who joined Institute of F...

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The Ludwig Maximilian University of Munich is...

2021-03-30

A three-year funded postdoc position is currently available in the laboratory of Maria Robles, Systems Chronobiology, at the LMU Munich, ...

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Kickoff Meeting

2021-01-21

The REVEAL project has officially started.

On the January 21st, 2021 REVEAL project's consortium met remotely to launch the pro...

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Launch of REVEAL project

2021-01-03

Launch of REVEAL, an innovative project aimed at imaging live cells in 2D and 3D by installing an innovative microscope at the interface ...

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